How Does Chelorex Work for Chelation?
Chelorex® Synergistic Oral Chelation Formula (Caplet Formula DG81P)
Click for Chelorex® Caplet Supplement Facts (Ingredient List)
Chelorex® was formulated to work synergistically to mobilize toxic heavy metals from within the body and protect the body from heavy metal reabsorption and redistribution. Below is a list of the 12 individual ingredients in the current Chelorex® (DG81P) formula, along with a brief summary of their functions along with supporting references and Study Summary Charts of Chelorex®
Check out The Ingredient Label for Chelorex caplets
Vitamin E (as d-alpha-tocopherol succinate): Brief Functional Summary: Antioxidant, supports thyroid function. Chang, L.W , Gilbert,M and Sprecher,J: Modification of methylmercury neurotoxicity by vitamin E, Environ.Res. 1978;17:356-366
Selenium (as sodium selenite): Brief Functional Summary:Enhances chemical detoxification, reduces toxicity of metals, necessary for conversion of T4 to T3 for normal thyroid function. Selenium is an important constituent of glutathione peroxidase, which breaks down toxic peroxides and free radicals. It has been shown to significantly reduce heavy metals.
Yoneda S, Suzuki KT Detoxification of mercury by selenium by binding of equimolar Hg-Se complex to a specific plasma protein. Toxicol Appl Pharmacol 1997;143(2):274-280 Johansson E: Selenium and its protection against the effects of mercury and silver. J Trace Elements 1991;5:273-274Gailer J; George GN; Pickering IJ, et al. Structural Basis of the Antagonism between Inorganic Mercury and Selenium in Mammals. Chem Res Toxicol 2000 Nov 20;13(11):1135-1142
Vitamin C (as ascorbic acid): Brief Functional Summary: Promotes excretion of toxic metals, essential antioxidant, supports thyroid function. Vitamin C is known to enhance the excretion of toxic metals in the gut and to protect against free radical damage.
Hill, CH. Interactions of vitamin C with lead and mercury. Ann N Y Acad Sci 1980;355:262-6 Yamini B, Sleight SD. Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs J Environ Pathol Toxicol Oncol 1984 Jul;5(4-5):139-50 Zorn NE, Smith JT A relationship between vitamin B12, folic acid, ascorbic acid, and mercury uptake and methylation. Life Sci 1990;47(2):167-73 Iyengar GV; Nair PP. Global outlook on nutrition and the environment: meeting the challenges of the next millennium. Sci Total Environ 2000 Apr 17;249(1-3):331-46.
Zinc (as zinc citrate): Brief Functional Summary: Stimulates metallothionine, reduces toxicity of metals.
Journal of Orthomolecular Psychiatry 7 (2):94-106 1978Flora SJ, Tandon SK: Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats, Toxicology, 1990 Nov; 64(2):129-39
Magnesium (as magnesium aspartate): Brief Functional Summary: Aids in chelation, replaces lost or chelated magnesium, protects against free radical damage. Assists in removing lead and other toxic metals. Reduces free radical damage from radiation and toxic substances.
1) Chugh SN, Kolley T, Kakkar R, Chugh K, Sharma A., A critical evaluation of anti-peroxidant effect of intravenous magnesium in acute aluminum phosphide poisoning. 2) 235: Soldatovic D, Vujanovic D, Matovic V, Plamenac Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. Magnes Res. 1997 Jun;10(2):127-33. PMID: 9368233, 3) 321: Soldatovic D, Matovic V, Vujanovic D. Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes Res. 1993 Jun;6(2):145-8. PMID: 8274359
Alpha-Lipoic Acid:a must for chelation! Brief Functional Summary: Binds intracellular toxic metals, quenches free radicals and raises glutathione levels. Alpha lipoic acid is a sulfur-containing co-factor for many essential biochemical reactions with potent antioxident properties. It is lipid and water soluble and can penetrate the blood brain barrier. This helps to remove toxic metals from the CNS.
Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Ziegler C, et al: Alpha-lipoic acid in the treatment of diabetic neuropathy in Germany: current evidence from clinical trials, Experimental & Clinical Endocrinology & Diabetes 1999;107(7):421-30.Gregus Z, et al: Effect of lipoic acid on biliary excretion of glutathione and metals, Toxicology & Applied Pharmacology 1992 May;114(1):88-96.
Taurine: Brief Functional Summary: Enhances biliary excretion, protects CNS , retina, and white blood cells. Taurine is a conditionally essential sulfur containing amino acid found in meat, fish, eggs and dairy products that appears to function as a neuromodulator and protective antioxidant in the CNS, where it is present in large amounts. Taurine levels are reduced in patients with lead poisoning. Taurine also protects the kidneys and retina from free radical damage by toxic metals and also protects the liver, heart, lungs and neutrophiles. Taurine has also been shown to enhance the secretion of toxic metals in bile.
Chesney, R.W. et al: Role of taurine in infant nutrition, Adv Exp Med Biol 1998 442: 463-76. Stapleton PP et al: Host Defense – a role for the amino acid taurine? J Parenter Enteral Nutr. 1998 Jan-Feb;22(1):42-8. Schuller-Levis GB, Park E: Taurine- new implications for an old amino acid. FEMS Microbiol Lett. 2003 Sep 26;226(2):195-202. Redmond HP et al. Immunonutrition – the role of taurine. Nutrition 1998 Jul-Aug; 14(7-8):599-604 Kontny E et al:The mechanism of taurine –choramine inhibition of cytokine production by rheumatoid arthritis fibroblast-like synoviocytes; Arthritis Rheum 2000 Oct,43(10):169-77.
Cracked Cell Chlorella: Brief Functional Summary: Traps toxic metals in the GI tract. Acts as an ion exchange resin. Chlorella is a species of unicellular fresh water algae that has been shown to possess detoxifying properties enabling it to assist or support the human detoxification system. Chlorella algae contain phytochemicals that support Phase I and Phase II detoxification reactions while the cell walls function as an ion exchange resin to absorb and retain toxic metals which can then be excreted. Chlorella can be used as a significant source of nutrients including vitamins, amino acids, fatty acids and minerals. They possess no toxicity and 20 grams or more can be ingested daily without any adverse effect.
H.B.Xue, W.Stumm, L.Sigg: The binding of Heavy Metals to Algal Surfaces, Water Res 1988;22, 917Carr HP, et al. Characterization of the cadmium-binding capacity of Chlorella vulgaris. Bull Environ Contam Toxicol. 1998;60(3): 433-440M.Kraft: Bindungsverhalten von Arsen, Cadmium, Chrom, Quecksilber, Nickel und Blei an schwerverdauliche Lebensmittel und Lebensmittelkomponenten in kuenstlichem Magen-Darm-Saft. PhD Thesis. Institut fuer Hygiene, Sozial-und umweltmedizin der Ruhr-Universitaet Bochum, Germany, (1998)Ahner, AB, Kong KS, Morell MM, Phytochelatin production in marine algea: An interspecies comparison. Limnol Oceanograph 1995;40: 649-657Northcote DH et al, 1958 The chemical composition and structure of the cell wall of Chlorella pyrenoidosa. .Biochem J 70:391-97.
Cilantro (aerial parts) (from 10:1 extract): Brief Functional Summary: Mobilizes toxic metals from the central nervous system and other tissues. Cilantro is a vegetable in the parsley family shown by Omura and others to be an effective chelator of CNS toxic metals. Its active component is a mercaptan that can penetrate the blood brain barrier.
MSM (methylsulfonylmethane): Brief Functional Summary: Enhances permeability of cell membranes. Methyl sulfonyl methane or MSM is a naturally occurring sulfur containing molecule found in fruits, vegetables, seafood and meat. It is present in the body and humans excrete from 4-11 mg. daily in urine. Research suggests that it is required for the body to preserve normal function and structure. Its toxicity is about equal to water. Food processing destroys the MSM normally present in food. MSM aids in detoxifying metals by contributing sulfur to methionine and cysteine as well as peptides and proteins and is eventually incorporated into connective tissue. It is also believed to enhance detoxification by increasing the permeability of cell walls. Recommended dosage for continuous use is 3000-6000 mg/day. When starting MSM some individuals may experience transient diarrhea, headache, skin rash, or fatigue associated with the release of toxins.
Jacob, Stanley W, M.D., Lawrence, Ronald M, M.D., PhD, Zucker, Martin The Miracle of MSM, The Natural Solution for Pain New York: Berkley Books 1999
L-Glutamine: Brief Functional Summary: Restores and preserves gastro-intestinal function, enhances hair excretion, glutathione precursor Glutamine is utilized as a source of energy and for nucleotide synthesis in all rapidly dividing cells. Hair follicles depend on it for energy production so that it assists the hair follicle in excreting toxic metals and the lining of the intestine in resisting the effects of toxic metals. It also is involved in the detoxification of ammonia, which reduces ATP production and thus ammonia interferes with detoxification reactions that depend on adequate supplies of ATP. Glutamine is a substrate for glutathione, which plays a major role in the body’s antioxidant and detoxification defenses. Both glutamine and glutathione are reduced in lead toxicity.
Williams R. et al; Metabolism of freshly isolated human hair follicles capable of hair elongation: a glutaminolytic aerobic glucolytic tissue; J Invest Dermatol. 1993 June; 100(6):834-40 Fox AD et al; Effect of a glutamine-supplemented enteral diet on methotrexate induced enterocolitis. J Parenter Enteral Nutr. 1988 Jul-Aug, 12(4):325-31 Cao Y et al ;Glutamine enhances gut glutathione production; J Parenter Enteral Nutr.1998 Jul-Aug; 22(4):224-7 Wessner B, et al; Effect of single and combined supply of glutamine, glycine, n- acetylcysteine and R,S alpha lipoic acid on glutathione content of myelomonocytic cells. Clin Nutr. 2003 Dec;22(6):515-22. NAC(N-Acetylcysteine): Brief Functional Summary: Binds toxic metals, raises glutathione levels and acts as antioxidant.
Yim CY, et al: Use of N-acetylcysteine to increase intracellular glutathione during induction of antitumor responses by IL-2, Journal of Immunology, 1994 Jan 15; 152(12):5796-805.Meyer A, Buhl R, Magnussen H: The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis, European Respiratory Journal, 1994 Mar; 7(3):431-6 Chelorex® Product Testing Over four years of clinical results of 400+ "Trial Subjects" (and counting). ”Chart 1” (below) shows specific toxic metal reduction results for hair, urine & fecal compared to baseline analysis results after consuming 90 doses of Chelorex® (group averages).
“Chart 2” is a Provocation or Challenge period demonstrating Chelorex’s primary path of excretion of toxic metals at the 14th day of consuming Chelorex®. The data shows Chelorex® to cause the majority of the toxic metals to be eliminated via the gastrointestinal tract, (1280% Increase in fecally eliminated metals). The urinary excretion was much lower (19% Increase in Urine), demonstrating Chelorex® exhibits minimal burden on the kidneys as opposed to most synthetic pharmaceutical chelation protocols.
4 Year Study Showing Percentage of Toxic Metal Reduction
After 90 Doses of Chelorex® (90 days @1 dose per day or 45 days @ 2 doses per day). Some subjects consumed 90 doses over a longer period of time.
81 Trial Subjects (Pre & Post Hair Analysis), 38 Trial Subjects (Pre & Post Urine Analysis), 36 Trial Subjects (Pre & Post Fecal Analysis).
Clinical Testing Performed By: Cell Physics Organization & The Carolina Center for Integrative Medicine; Hair, Fecal & Urine Analysis Performed By: Doctors Data Inc.
Oral Chelation of Toxic Metals Works!
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